News

NEW COLLABORATION BETWEEN BIOINFOGATE AND INTAGE HEALTHCARE TO DELIVER JAPANESE PHARMACOVIGILANCE INSIGHTS IN OFF-X

Tokyo / Barcelona.

Bioinfogate will integrate JADER case reports and pharmacovigilance signals into OFF-X to complement its unique translational view of safety intelligence.

Bioinfogate, a leading healthcare data science organization, today announced it has entered into a global agreement with INTAGE Healthcare (hereafter “INTAGE”) to integrate Japanese pharmacovigilance insights from the JADER database (the Pharmaceuticals and Medical Devices Agency (PMDA) database of spontaneous adverse drug reaction reports in Japan).

Based on its long standing experience managing and curating the JADER and FAERS databases, INTAGE will provide a curated dataset of case reports and derived signals to be integrated with OFF-X’s expertly curated safety data and analytics. INTAGE is the producer of the CzeekV Pro database system, offered since 2010, a curated database of FAERS and JADER spontaneous adverse reports and signals based on well-established methods used by a variety of regulatory bodies worldwide.

By delivering critical integrated target discovery, preclinical toxicity, clinical adverse event intelligence and pharmacovigilance insights coupled to advanced analytics, Bioinfogate OFF-X™ allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post-marketing. OFF-X is updated daily: more than 4,000 expertly curated alerts are added to the portal each week.

Launched in 2016, OFF-X is used across pharma and biotech organizations, in leading research centers and by regulatory bodies around the world, addressing the need for new approaches to enhance safety assessments that can reduce patient burden and avoid costly failures.

 

About Bioinfogate

Bioinfogate is a forward-thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying and investing in emerging projects that align with our core business in the life sciences and data analytics.

 

About Bioinfogate OFF-X

The Bioinfogate OFF-X™ portal provides integrated target discovery, non-clinical and clinical adverse event intelligence and pharmacovigilance insights for drugs and targets in all phases of drug R&D and post-marketing. As of October 2020, the portal covers a range of over 15,000 targets and almost 19,500 drugs & biologics, and is populated with more than 875,000 expertly curated safety alerts associated to over 9,000 adverse effects. OFF-X is used across pharma and biotech organizations, in leading research centers and regulatory bodies.

For more information visit www.targetsafety.info

 

About INTAGE Healthcare

INTAGE Healthcare combines deep knowledge of clinical practice with the INTAGE Group’s abundant resources and strength in consumer insights to provide healthcare consumers, providers, manufacturers, and service companies with the information they need to make healthier decisions.

For more information visit https://www.intage-healthcare.co.jp/

 

About INTAGE Healthcare CzeekV Pro

The INTAGE Healthcare CzeekV Pro is a system that searches publicly available spontaneously reported adverse event databases for the relationship between drugs and adverse events using statistical analysis methods. The system integrates JADER and FAERS, and calculates and registers score values indicating the relationship between “drugs-adverse events”. The score value is calculated as a statistical method to evaluate significance and adopts the same method as the world’s major regulatory institutions and displays four score values.

It is also equipped with an age-specific histogram, signal distribution map, detailed statistical analysis function by age and gender, and a report list browsing function, which are useful as safety monitoring tools and analysis tools.

For more information visit https://pro.czeek.com/

LAUNCH OF BIOINFOGATE’S OFF-X TRANSLATABILITY DASHBOARD

The Translatability Dashboard supports understanding of how toxicity events derived from experimental assays and animal models translate to the clinic

Bioinfogate is proud to announce the launch of the new OFF-X Translatability Dashboard. The Dashboard supports understanding of how toxicity events derived from experimental assays and animal models translate to the clinic, allowing researchers to prioritize experimental testing and anticipate potential safety issues when designing clinical trials and identify emerging class liabilities.

The translatability dashboard concept has been developed based on the unique and vast array of information in OFF-X, which spans over 14,000 targets of therapeutic interest and almost 800,000 individual alerts manually curated by the Bioinfogate editorial team in the last 5 years. The availability of data from knockout studies, human genetics and pharmacological intervention demonstrate how varying action at the molecular level (e.g. activation, inhibition, inactivation) of the pathway can lead to a benefit for –or in some cases detriment to –patients.

Bioinfogate OFF-X delivers actionable toxicity and safety intelligence to researchers and decision makers in pharmaceutical and healthcare organizations. By delivering critical integrated preclinical toxicity and clinical adverse event intelligence coupled to advanced analytics, Bioinfogate OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post-marketing. OFF-X provides integrated information for drugs and targets in all phases of drug R&D, including first-in-class and emerging targets.

The OFF-X Translatability Dashboard can be used in a variety of drug R&D scenarios, including target safety assessments, mechanistic understanding of potential toxicity issues, identifying ways and models that could be used to monitor or assess adverse events, building new panels for off-target assessment, understanding differences in effect between healthy volunteers and diseased patients to support clinical efficacy/safety findings, and analyzing reverse translation from clinical/post-marketing adverse events.

Dr Josep Prous, Jr, Executive Director at Bioinfogate commented: “We are very pleased to add this new functionality in OFF-X and to position the tool as a unique translational safety intelligence portal, from early target discovery to pharmacovigilance needs. This responds to the needs of our customers in pharmaceutical research organizations, regulatory bodies and clinical research organizations who rely on OFF-X as a unique resource in the finding of safer drugs in any therapeutic area of interest.”

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying / investing in emerging projects that align with our core business in the life sciences and data analytics.
Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007), acquired by Thomson Reuters in 2007 (now Clarivate Analytics), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

FDA AND BIOINFOGATE AGREE TO EXTEND THE MATERIAL TRANSFER AGREEMENT (MTA) TO PROVIDE AGENCY-WIDE ACCESS TO THE OFF-X TRANSLATIONAL SAFETY INTELLIGENCE PORTAL

The agreement aims to evaluate new approaches to enhance safety assessments of human pharmaceuticals and their associated molecular targets, supporting the FDA’s mission of protecting public health.

Under this MTA, the FDA has agency-wide access to Bioinfogate’s translational safety intelligence portal, OFF-X. The primary objective of the agreement is to evaluate the potential use of Bioinfogate OFF-X™ as a research tool to anticipate adverse events associated with molecular targets and evaluate its utility in the regulatory review process. In addition and as the collaboration enters its third year extension, the FDA will continue to provide feedback on the utility of the OFF-X database and/or any aspects related to new functions.

Unexpected safety issues constitute one of the most disruptive events in clinical research. A translational approach to drug safety that integrates preclinical and clinical data can significantly reduce patient burden and avoid costly failures. In this context, it is essential to detect as early as possible in the drug R&D process the potential safety liabilities associated with new targets, drugs under development and recently marketed compounds.

About FDA CDER

FDA/CDER performs an essential public health task by making sure that safe and effective drugs are available to improve the health of people in the United States. As part of the FDA, CDER regulates over-the-counter and prescription drugs, including biological therapeutics and generic drugs. FDA/CDER’s mission is to protect and promote public health by helping to ensure that human drugs are safe and effective, meet established quality standards, and are available to patients.

About Bioinfogate OFF-X

Bioinfogate, a leading data science organization, is the producer of the OFF-X translational safety intelligence portal (https://www.targetsafety.info/). By delivering critical integrated preclinical toxicity and clinical adverse event intelligence coupled to advanced analytics, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and post-marketing. Updated daily with expertly curated safety alerts and as of May 2020, the portal covers a range of close to 15,000 targets and over 16,000 drugs & biologics, and is populated with more than 670,000 expertly curated safety alerts associated to over 8,000 adverse effects. OFF-X covers targets and drugs in all stages of drug R&D from emerging and first-in-class targets to drugs that have reached the market. OFF-X aims to promptly identify toxicology and safety signals and de-risk R&D programs. For more information please contact us at info@bioinfogate.com.

BIOINFOGATE’S OFF-X PROVIDES A DEDICATED “COVID-19” SECTION

The COVID-19 section features the latest safety alerts related to drugs being investigated as potential treatments, vaccinations or supportive care. 

To complement the efforts being made worldwide in the fight against COVID-19, Bioinfogate is pleased to announce that they are providing complimentary access to a dedicated “COVID-19” section in OFF-X, the translational safety information portal. This section features the latest safety alerts related to drugs being investigated as potential treatments, vaccinations or supportive care. 

Updated as soon as new information becomes available, the COVID-19 section provides a compilation of safety alerts derived from recent publications related to COVID-19 as well as previous OFF-X content that may be of interest.

Dr Josep Prous, Jr, Executive Director at Bioinfogate commented: “We are very pleased to be able to contribute to the global efforts being made to tackle this pandemic, by helping optimize pharmaceutical R&D and minimize patient risks in clinical trials and beyond”.

The COVID-19 report can be accessed via the OFF-X home page, from the Selected Daily Alerts section. Content can be sorted and/or filtered by target, drug of interest or date. Clicking on any alert jumps to OFF-X and the full alert details.

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying / investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007), acquired by Thomson Reuters in 2007 (now Clarivate Analytics), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

BIOINFOGATE’S OFF-X REACHES HALF MILLION SAFETY ALERTS

OFF-X has become the largest translational safety and toxicity intelligence portal for drugs and targets of pharmacological interest.

Barcelona, January 13, 2020

Launched in 2017, OFF-X has now reached 500,000 curated safety alerts corresponding to almost 15,000 targets of pharmacological interest and almost 14,500 drugs and biologics.

Unexpected safety issues still constitute one of the major challenges in drug R&D and clinical practice. It is therefore essential to rapidly identify these issues and react accordingly to minimize risks in pharmaceutical programs.

To help in this endeavor, Bioinfogate has developed OFF-X, the translational safety intelligence portal, which provides integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of R&D, including first-in-class and emerging targets.

The database is updated daily with information deriving from biomedical literature, congresses and scientific conferences, company communications, major clinical trial registries, pharmacovigilance data and regulatory agencies, and includes data from the last 50 years.

On reaching this milestone Dr Josep Prous, Jr, Executive Director at Bioinfogate commented:

“We are very pleased that OFF-X has become an essential tool for all those involved in finding better and safer drugs. Our editorial team – comprised of specialists in multiple biomedical research disciplines – has made an outstanding contribution in producing such a large amount of curated information. We look forward to further developing the platform to help optimize pharmaceutical R&D and minimize patient risks in clinical trials and beyond”.

By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and postmarketing. OFF-X is used across a wide range of departments in pharmaceutical research organizations, public health institutions and regulatory agencies.

Along with the large amount of information available in OFF-X, a series of advanced analytics allow users to fully exploit the OFF-X dataset.

 

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying / investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007), acquired by Thomson Reuters in 2007 (now Clarivate Analytics), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

BIOINFOGATE SUCCESSFULLY COMPLETES NEOTEC PROJECT SUPPORTED BY CDTI (CENTER FOR THE DEVELOPMENT OF INDUSTRIAL TECHNOLOGY)

Barcelona, December 31, 2019

Bioinfogate is pleased to announce successful completion of the R&D innovation project “DEVELOPMENT OF AN ARTIFICIAL INTELLIGENCE PLATFORM TO ANTICIPATE AND MINIMIZE THE RISKS ASSOCIATED WITH THE SAFETY OF DRUGS FROM THEIR PHASE OF DISCOVERY THROUGH THEIR USE IN CLINICAL PRACTICE”.

The program has been supported by the CDTI (Center for the Development of Industrial Technology) NEOTEC initiative.

The NEOTEC program aims to support the creation and consolidation of technology-based companies (TBCs). A TBC is defined as a company that makes use of products or services that need technologies or knowledge developed from research activity. The business strategy of a TBC requires mastery of scientific and technical knowledge. The most important aspect of the proposals considered for this grant is a business strategy based on technological development (technology must be the company’s defining competitive factor) from the company’s own R&D.

Dr Josep Prous, Jr, Executive Director at Bioinfogate commented: “We are very honored to have been supported by CDTI’s NEOTEC program, and to have successfully completed the surrounding technological and business objectives. This institutional support has proven instrumental in accelerating Bioinfogate’s innovation and growth.”

Details on the specific details of CDTI’s NEOTEC program can be found here.

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying / investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007), acquired by Thomson Reuters in 2007 (now Clarivate Analytics), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

About CDTI

The Centre for the Development of Industrial Technology (CDTI) reports to the Ministry of Economy, Industry and Competitiveness and fosters the technological development and innovation of Spanish companies. It channels funding and support applications for national and international R&D&I projects. CDTI’s roles include financial and economic-technical assessment of R&D projects, managing and fostering participation in international technological cooperation programs, fostering international business technology transfer and supporting the set-up and consolidation of technological companies.

BIOINFOGATE TO PRESENT AT THE CHEM-BIO INFORMATICS SOCIETY (CBI) ANNUAL MEETING (TOKYO, JAPAN, OCTOBER 22-24, 2019)

October 10, 2019

Bioinfogate has been invited to a speak at the Chem-Bio Informatics Society (CBI) Annual Meeting “”Towards Seamless Integration of Structural Biology and Information Science”~Dawn of the AI era in drug discovery~” which takes place in Tokyo, Oct. 22-24, 2019.

During the Focused Session FS13 “Computational toxicology – practical and application”, (Wed Oct. 23, 16:00-17:30), Dr Josep Prous, Jr., Executive Director at Bioinfogate will present “THE IMPORTANCE OF A SOLID KNOWLEDGE MANAGEMENT STRATEGY IN COMPUTATIONAL TOXICOLOGY”.

Given the continuous growth of safety and toxicity information, it is essential to design an adequate knowledge management plan to identify the most relevant safety hotspots to be analyzed in the context of a research project.

In his presentation, Dr Prous, Jr. will explain how the availability of a large amount of high quality, manually curated information has allowed scoring functions to be developed in order to identify safety hotspots which may be readily applicable in computational toxicology programs.

This approach has been integrated into the OFF-X translational safety intelligence portal which provides integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of drug R&D, including first-in-class and emerging targets.

For further information or to schedule a meeting during the conference, please contact info@bioinfogate.com.

 

About the Chem-Bio Informatics Society  

The Chem-BioInformatics (CBI) Society is a Japanese non-profit organization that aims to provide a platform for promoting cutting-edge interdisciplinary areas related to chemistry, biology, and informatics. The CBI Society is interested in molecular recognition and molecular modeling, in silico drug discovery, bioinformatics and their applications in medicine, information and computing approaches for drug design and ADMET studies, and emerging new technologies.

 

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry leading solutions and also identifying and investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007), acquired by Thomson Reuters in 2007 (now Clarivate Analytics), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

BIOINFOGATE EXHIBITING AT THE SAFETY PHARMACOLOGY SOCIETY ANNUAL MEETING IN BARCELONA (SEPTEMBER 23-25, 2019)

Barcelona, September 20, 2019

Bioinfogate will be showcasing some of their recent developments at the Safety Pharmacology Society Annual Meeting in Barcelona, September 23-26, 2019.

At the exhibition (booth 601), the latest version of our translational safety intelligence portal OFF-X will be presented, including the OFF-X Score (a tool to identify the degree of association between targets/drugs and adverse effects in the corpus of more than 410,000 alerts in OFF-X), and new analytics enhancements such as the comparative drug safety heatmaps, the mounting evidence chart and the comparative table builder.

Since its launch in 2017, Bioinfogate OFF-X has been providing integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of R&D, including first-in-class and emerging targets. OFF-X allows prompt identification of toxicology and safety signals and de-risking of R&D projects. As of September 2019, the portal covers a range of almost 8,200 targets and 14,000 drugs & biologics, and is populated with more than 410,000 expertly curated safety alerts and 500,000 references of interest associated to 5,000 adverse effects. OFF-X is used across pharma and biotech organizations, in leading research centers and regulatory bodies (for more information visit www.targetsafety.info).

A series of case studies will be presented to demonstrate OFF-X’s utility for a wide variety of professionals including:

  • Biologists and Bioinformaticians, to perform new target safety assessment
  • Medicinal Chemists, to identify potential toxicophores and optimize hit compounds
  • Data Scientists, to build predictive and AI models using OFF-X’s high quality curated and structured dataset
  • Toxicologists and Non-Clinical Safety Researchers, to analyze data for regulatory endpoints of interest, assess secondary pharmacology and potential off-target liabilities
  • Clinical Researchers, to optimize clinical trial design, understand mechanistic toxicity of adverse events observed in clinical trials and to benchmark competitors’ safety profiles
  • Pharmacovigilance teams to discover unknown adverse events and support understanding of safety alerts
  • Regulatory professionals, to facilitate mandatory reporting requirements of regulatory bodies
  • Business Development Analysts, to enhance due diligence of potential in-licensing opportunities

For further information or to schedule a meeting during the conference, please contact info@bioinfogate.com.

 

About the Safety Pharmacology Society

The Safety Pharmacology Society is a nonprofit organization that promotes knowledge, development, application, and training in safety pharmacology. It aims to bridge disciplines to predict, identify, characterize, monitor, and mitigate potentially undesirable pharmacodynamic activities in nonclinical studies and guide their translation into clinical trials and beyond, to benefit all patients.

 

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying and investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007; acquired by Thomson Reuters in 2007), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

RESEARCH INSTITUTES OF SWEDEN (RISE) INITIATES SUBSCRIPTION TO BIOINFOGATE OFF-X

Barcelona, June 20, 2019

 

Bioinfogate announced today the signing of a licensing agreement with RISE to access Bioinfogate’s translational safety intelligence portal, OFF-X.

RISE selected OFF-X to support the work of researchers in drug R&D to perform target safety assessment for early projects. The agreement involves the use of OFF-X safety intelligence portal to more quickly and precisely identify potential adverse events resulting from treatment with new and existing drugs.

By delivering critical integrated preclinical toxicity and clinical adverse event intelligence coupled to advanced analytics, Bioinfogate OFF-X™ allows safety liabilities to be monitored and anticipated across all phases of drug R&D. Updated daily with expertly curated safety alerts, as of June 2019, the portal covers a range of 7,700 targets and more than 10,000 drugs & biologics, and is populated with more than 340,000 alerts associated to 5,000 adverse effects. OFF-X covers targets and drugs in all stages of drug R&D development from emerging and first-in-class targets to drugs that have reached the marketplace. OFF-X aims to promptly identify toxicology & safety signals and de-risk R&D programs.

“We are very pleased that RISE is joining the growing number of leading research institutions using OFF-X as an essential tool for their drug safety and toxicology related activities” commented Josep Prous, Jr., Executive Director, Bioinfogate.

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Bioinfogate helps companies, academic institutions, and government and regulatory agencies working in scientific research and drug R&D. Our innovative knowledge management tools and analytics software solutions support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying and investing in emerging projects that align with our core business in life sciences and data analytics.

Our passion and capabilities stem from more than 60 years’ experience creating and managing biomedical knowledge, first at Prous Science (acquired by Thomson Reuters in 2007), and then at the Prous Institute for Biomedical Research. Bioinfogate is the next generation firm within the Prous family of companies, embracing a long tradition and expertise in scientific knowledge management.

For more information please contact us at media@bioinfogate.com.

VHIO AND BIOINFOGATE PARTNER TO ENHANCE SAFETY ASSESSMENT IN CLINICAL RESEARCH

Announced today, the Vall d´Hebron Institute of Oncology – Bioinfogate collaboration will validate the utility of the OFF-X translational safety intelligence portal in the design of novel clinical trials, including first-in-human studies.

Barcelona, June 17, 2019

The Vall d´Hebron Institute of Oncology (VHIO) and Bioinfogate have launched a collaborative agreement to analyze new opportunities in optimizing safety assessment and minimizing patient risk in oncology clinical trials. This partnership will seek to establish how integrating preclinical toxicity and clinical safety intelligence facilitates a translational research approach and increases understanding of the safety profile of new treatments.

The agreement involves the use of publicly available information published in Bioinfogate’s OFF-X translational safety intelligence portal to more quickly and precisely identify potential adverse events resulting from treatment with new therapies that are either about to enter clinical trials or are under current clinical development.

A first milestone of the collaboration will be to assess the value of the new OFF-X Score system to identify the degree of association between targets/drugs and adverse effects in the corpus of more than 340,000 alerts available in OFF-X.

Throughout this collaboration, VHIO will bring its renowned expertise and know-how in pioneering early clinical drug development to evaluate and advise on newly introduced functionalities of the OFF-X platform. These efforts focus on advancing and accelerating the development of more effective and safer anti-cancer therapies, set firmly within the context of precision medicine in oncology.

“Only by factoring in important preclinical insights into clinical study design will we be better equipped to predict, ameliorate and alleviate side effects experienced by patients participating in clinical trials, now and in the future” commented Elena Garralda, Director of VHIO’s Research Unit for Molecular Therapy of Cancer (UITM) – “la Caixa”, and Principal Investigator of its Early Clinical Drug Development.

“Toxicity and safety assessment represent, along with a deeper understanding of disease processes, next generation experimental models and biomarkers, one of the cornerstones of finding and developing new anticancer therapies. We are very pleased to partner with VHIO, a leading research organization in the field, to demonstrate the usefulness of OFF-X in the clinical setting” commented Josep Prous, Jr., Executive Director, Bioinfogate.

 

About Vall D’Hebron Institute of Oncology

Established in 2006, the Vall d´Hebron Institute of Oncology (VHIO) is a leading comprehensive cancer center of excellence where scientists and research physicians adopt a purely translational research model and work together as multidisciplinary teams to accelerate and advance personalized and targeted therapies against cancer. Undertaking one of Spain’s most dynamic cancer research programs, VHIO is dedicated to delivering on the promise of precision medicine in oncology – turning cancer discovery into more effective treatments and better practice for the care of their patients. Located within the Vall d’Hebron Barcelona Hospital Campus, translational science and clinical research are tightly connected and promote the necessary interaction and teamwork to accelerate the bench-bedside-bed cycle of knowledge. VHIO’s pioneering model and programs, coupled with its belief in combining strengths through cross-border collaborations, continue to spur advances in reversing cancer resistance, halting metastatic cell spread, and more effectively treating even the most undruggable tumor types.

 

About Bioinfogate OFF-X™

Bioinfogate, a leading data science organization, is the producer of the OFF-X translational safety intelligence portal (www.targetsafety.info). By delivering critical integrated preclinical toxicity and clinical adverse event intelligence coupled to advanced analytics, Bioinfogate OFF-X™ allows safety liabilities to be monitored and anticipated across all phases of drug R&D. Updated daily with expertly curated safety alerts, as of June 2019, the portal covers a range of 7,700 targets and more than 10,000 drugs & biologics, and is populated with more than 340,000 alerts associated to 5,000 adverse effects. OFF-X covers targets and drugs in all stages of drug R&D development from emerging and first-in-class targets to drugs that have reached the marketplace. OFF-X aims to promptly identify toxicology & safety signals and de-risk R&D programs.

For more information please contact us at media@bioinfogate.com

BIOINFOGATE EXHIBITING AT WORLD PHARMA WEEK IN BOSTON, MA (JUNE 17-20, 2019)

June 14, 2019  

Bioinfogate will be showcasing some of their recent developments at World Pharma Week in Boston, MA, June 17-20 2019.

At the exhibition (booth 133, shared with Chemotargets), the latest version of the translational safety intelligence portal OFF-X will be presented, including new features like the OFF-X Score – a tool to identify the degree of association between targets/drugs and adverse effects in the corpus of more than 340,000 alerts available in OFF-X.

Since its launch in 2017, Bioinfogate OFF-X has been providing integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of R&D, including first-in-class and emerging targets. OFF-X allows prompt identification of toxicology and safety signals and de-risking of R&D projects. As of June 2019, the portal covers a range of 7,700 targets and 10,000 drugs & biologics, and is populated with more than 340,000 expertly curated safety alerts and 500,000 references of interest associated to 5,000 adverse effects. OFF-X is used across pharma and biotech organizations, in leading research centers and regulatory bodies (for more information visit www.targetsafety.info).

A series of case studies will be presented to demonstrate OFF-X’s utility for a wide variety of professionals including:

  • Biologists and Bioinformaticians, to perform new target safety assessment
  • Medicinal Chemists, to identify potential toxicophores and optimize hit compounds
  • Data Scientists, to build predictive and AI models using OFF-X’s high quality curated and structured dataset
  • Toxicologists and Non-Clinical Safety Researchers, to analyze data for regulatory endpoints of interest, assess secondary pharmacology and potential off-target liabilities
  • Clinical Researchers, to optimize clinical trial design, understand mechanistic toxicity of adverse events observed in clinical trials and to benchmark competitors’ safety profiles
  • Pharmacovigilance teams to discover unknown adverse events and support understanding of safety alerts
  • Regulatory professionals, to facilitate mandatory reporting requirements of regulatory bodies
  • Business Development Analysts, to enhance due diligence of potential in-licensing opportunities

For further information or to schedule a meeting during the conference, please contact info@bioinfogate.com.

 

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying and investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007; acquired by Thomson Reuters in 2007), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

FDA AND BIOINFOGATE AGREE TO EXTEND THE MATERIAL TRANSFER AGREEMENT (MTA) TO ACCESS THE OFF-X TRANSLATIONAL SAFETY INTELLIGENCE PORTAL

Barcelona, May 21, 2019.

The agreement aims to evaluate new approaches to enhance safety assessments of human pharmaceuticals and their associated molecular targets, supporting the FDA’s mission of protecting public health.

Under this MTA, the FDA has agency-wide access to Bioinfogate’s translational safety intelligence portal, OFF-X. The primary objective of the agreement is to evaluate the potential use of Bioinfogate OFF-X™ as a research tool to anticipate adverse events associated with molecular targets and evaluate its utility in the regulatory review process. Under the recently extended agreement, the FDA will continue to provide feedback on the utility of the OFF-X database and/or any aspects related to its functioning and use.

Unexpected safety issues constitute one of the most disruptive events in clinical research. A translational approach to drug safety that integrates preclinical and clinical data can significantly reduce patient burden and avoid costly failures. In this context, it is essential to detect as early as possible in the drug R&D process the potential safety liabilities associated to both new targets and drugs under development.


About FDA CDER

FDA/CDER performs an essential public health task by making sure that safe and effective drugs are available to improve the health of people in the United States.  As part of the FDA, CDER regulates over-the-counter and prescription drugs, including biological therapeutics and generic drugs.  FDA/CDER’s mission is to protect and promote public health by helping to ensure that human drugs are safe and effective, meet established quality standards, and are available to patients.

About Bioinfogate OFF-XTM

Bioinfogate, a leading data science organization, is the producer of the OFF-X translational safety intelligence portal (https://www.targetsafety.info/). By delivering critical integrated preclinical toxicity and clinical adverse event intelligence coupled to advanced analytics, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D. Updated daily with expertly curated safety alerts and as of June 2019, the portal covers a range of 7,600 targets, close to 10,000 drugs & biologics, and is populated with more than 315,000 expertly curated safety alerts associated to 5,000 adverse effects. OFF-X covers targets and drugs in all stages of drug R&D from emerging and first-in-class targets to drugs that have reached the market. OFF-X aims to promptly identify toxicology and safety signals and de-risk R&D programs.

NEW ALLIANCE BETWEEN CLARIVATE ANALYTICS AND BIOINFOGATE TO DELIVER SAFETY & TOXICITY INTELLIGENCE TO PHARMA AND HEALTHCARE RESEARCHERS AND DECISION MAKERS

Philadelphia / Barcelona, February 28, 2019

Bioinfogate will cross-link the OFF-X translational safety intelligence portal with the Cortellis suite of solutions from Clarivate Analytics to enable enhanced insights for targets and drugs of interest

Bioinfogate, a leading healthcare data science organization, today announced it has into a global agreement with Clarivate Analytics to cross-link the OFF-X safety intelligence portal with Cortellis preclinical intelligence. In addition, Clarivate will leverage its commercial footprint to expand OFF-X usage to life science professionals who are benefiting from Cortellis, its suite of life sciences data and analytics solutions. The agreement makes it easier for customers to integrate, access and apply toxicity and adverse events intelligence across all phases of drug research and development (R&D).

Toxicity and adverse events cause more than 30% of drugs to fail during the R&D process, which costs the industry approximately $35 billion each year. OFF-X is used across pharma and biotech organizations, in leading research centers and by regulatory bodies around the world, addressing the need for new approaches to enhance early safety assessments that can reduce patient burden and avoid costly failures. Updated daily, OFF-X enables safety liabilities to be monitored and anticipated across all phases of drug R&D.

In this partnership, both organizations have also agreed to identify, develop and deploy new capabilities, including additional platform cross-linking, content syndication, and API-enabled integration to ensure interopability. Cortellis drug and target ontologies are used within OFF-X to provide platform linkages, which pave the way for enhanced data delivery.

“We are pleased to partner with Clarivate Analytics to expand and accelerate the reach of our safety and toxicology data assets,” commented Josep Prous, Jr., Executive Director, Bioinfogate. “We look forward to expanding the OFF-X value proposition by giving researchers and regulators access to complementary data, analytics and insights in Cortellis.”

“Ensuring drug safety is of vital importance to our industry, and enabling the interoperability between Cortellis and the OFF-X platform will help to advance this goal,” said Mukhtar Ahmed, President, Life Sciences, Clarivate Analytics. “Through this partnership, we’ll be able to significantly expand the reach – and utility – of critical drug efficacy and safety information to researchers around the world.”

 

About Bioinfogate
Bioinfogate is a forward-thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry leading solutions and identifying and investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years’ experience creating and managing biomedical knowledge, first at Prous Science (1958-2007, acquired by Thomson Reuters in 2007), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous Group of companies to embrace a long tradition and expertise in scientific knowledge management.

For more information visit www.bioinfogate.com

 

About Bioinfogate OFF-XTM
The Bioinfogate OFF-XTM portal provides integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of drug R&D, including first-in-class and emerging targets. OFF-X allows prompt identification of toxicology & safety signals and de-risking of R&D projects. As of February 2019, the portal covers a range of 15,000 targets and 10,000 drugs & biologics, and is populated with more than 260,000 expertly curated safety alerts and 500,000 references of interest associated to 4,000 adverse effects. OFF-X is used across pharma and biotech organizations, in leading research centers and regulatory bodies

For more information visit www.targetsafety.info

 

About Cortellis
Cortellis gives life to science by unlocking the hidden insights in data. This industry-leading solution curates the broadest and deepest sources of intelligence to enable precise, actionable answers to specific questions across the R&D lifecycle — from discovery and clinical development through regulatory submission and commercialization. By supporting data-driven decisions, Cortellis helps pharmaceutical companies, biotech and medical device/diagnostic firms accelerate innovation. In 2017, 80% of U.S. companies filing NMEs, 91% of companies achieving breakthrough therapy status and 70% of the top licensing deals were informed by Cortellis intelligence.

To learn more, visit www.Clarivate.com/Cortellis

 

About Clarivate Analytics
Clarivate Analytics is a global leader in providing trusted insights and analytics to accelerate the pace of innovation. Building on a heritage going back more than a century and a half, we have built some of the most trusted brands across the innovation lifecycle, including the Web of Science, Cortellis, Derwent, CompuMark, MarkMonitor and Techstreet. Today, Clarivate Analytics is a new and independent company on a bold entrepreneurial mission, to help our clients radically reduce the time from new ideas to life-changing innovations.

For more information, please visit www.clarivate.com.

 

Forward-Looking Statements
This press release and oral statements made with respect to information contained in this release may contain forward-looking statements regarding Clarivate Analytics. Forward-looking statements provide Clarivate Analytics’ current expectations or forecasts of future events and may include statements regarding anticipated synergies and other future expectations. These statements involve risks and uncertainties including factors outside of Clarivate Analytics’ control that may cause actual results to differ materially. Clarivate Analytics undertakes no obligation to update or revise the statements made herein, whether as a result of new information, future events or otherwise.

 

Media Contacts:
BioInfogate
info@bioinfogate.com

Clarivate Analytics
media.enquiries@clarivate.com

Download this article Clarivate and Bioinfogate partnership agreeement PR 20190225

BIOINFOGATE EXHIBITING AT THE SOCIETY OF TOXICOLOGY’S 58TH ANNUAL MEETING AND TOXEXPO IN BALTIMORE, MD (MARCH 10-14, 2019)

Feb 15, 2019

Bioinfogate will be showcasing some of their recent developments at the Society of Toxicology’s 58th Annual Meeting and ToxExpo in Baltimore, MD, March 10-14 2019.

At the exhibition (booth 4210), the latest version of our translational safety intelligence portal OFF-X will be presented, including new and forthcoming enhancements like the expansion of the Drugs&Biologics area or the launch of the Additional References section, developed in order to expand the coverage of targets in the system.

A series of case studies will be presented to demonstrate OFF-X’s utility for a wide variety of professionals including:

  • Biologists and Bioinformaticians, to perform new target safety assessment
  • Medicinal Chemists, to identify potential toxicophores and optimize hit compounds
  • Data Scientists, to build predictive and AI models using OFF-X’s high quality curated and structured dataset
  • Toxicologists and Non-Clinical Safety Researchers, to analyze data for regulatory endpoints of interest, assess secondary pharmacology and potential off-target liabilities
  • Clinical Researchers, to optimize clinical trial design, understand mechanistic toxicity of adverse events observed in clinical trials and to benchmark competitors’ safety profiles
  • Pharmacovigilance teams to discover unknown adverse events and support understanding of safety alerts
  • Regulatory professionals, to facilitate mandatory reporting requirements of regulatory bodies
  • Business Development Analysts, to enhance due diligence of potential in-licensing opportunities

Since its launch in 2017, Bioinfogate OFF-X has been providing integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of R&D, including first-in-class and emerging targets. OFF-X allows prompt identification of toxicology and safety signals and de-risking of R&D projects. As of February 2019, the portal covers a range of 7,000 targets and 9,000 drugs & biologics, and is populated with more than 260,000 expertly curated safety alerts and 500,000 references of interest associated to 4,000 adverse effects. OFF-X is used across pharma and biotech organizations, in leading research centers and regulatory bodies (for more information visit www.targetsafety.info).

For further information or to schedule a meeting during the conference, please contact info@bioinfogate.com.

 

About Society of Toxicology (SOT)

SOT, founded in 1961, is a professional and scholarly organization of scientists from academic institutions, government, and industry representing scientists who practice toxicology in the US and abroad. The Society’s mission is to create a safer and healthier world by advancing the science and increasing the impact of toxicology. The SOT Annual Meeting hosts 6,000+ participants from the fields of toxicology, safety, regulation, risk assessment and more.

 

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying and investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007; acquired by Thomson Reuters in 2007), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.