BIOINFOGATE TO PRESENT AT THE CHEM-BIO INFORMATICS SOCIETY (CBI) ANNUAL MEETING (TOKYO, JAPAN, OCTOBER 22-24, 2019)

October 10, 2019

Bioinfogate has been invited to a speak at the Chem-Bio Informatics Society (CBI) Annual Meeting “”Towards Seamless Integration of Structural Biology and Information Science”~Dawn of the AI era in drug discovery~” which takes place in Tokyo, Oct. 22-24, 2019.

During the Focused Session FS13 “Computational toxicology – practical and application”, (Wed Oct. 23, 16:00-17:30), Dr Josep Prous, Jr., Executive Director at Bioinfogate will present “THE IMPORTANCE OF A SOLID KNOWLEDGE MANAGEMENT STRATEGY IN COMPUTATIONAL TOXICOLOGY”.

Given the continuous growth of safety and toxicity information, it is essential to design an adequate knowledge management plan to identify the most relevant safety hotspots to be analyzed in the context of a research project.

In his presentation, Dr Prous, Jr. will explain how the availability of a large amount of high quality, manually curated information has allowed scoring functions to be developed in order to identify safety hotspots which may be readily applicable in computational toxicology programs.

This approach has been integrated into the OFF-X translational safety intelligence portal which provides integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of drug R&D, including first-in-class and emerging targets.

For further information or to schedule a meeting during the conference, please contact info@bioinfogate.com.

 

About the Chem-Bio Informatics Society  

The Chem-BioInformatics (CBI) Society is a Japanese non-profit organization that aims to provide a platform for promoting cutting-edge interdisciplinary areas related to chemistry, biology, and informatics. The CBI Society is interested in molecular recognition and molecular modeling, in silico drug discovery, bioinformatics and their applications in medicine, information and computing approaches for drug design and ADMET studies, and emerging new technologies.

 

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry leading solutions and also identifying and investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007), acquired by Thomson Reuters in 2007 (now Clarivate Analytics), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

BIOINFOGATE EXHIBITING AT THE SAFETY PHARMACOLOGY SOCIETY ANNUAL MEETING IN BARCELONA (SEPTEMBER 23-25, 2019)

Barcelona, September 20, 2019

Bioinfogate will be showcasing some of their recent developments at the Safety Pharmacology Society Annual Meeting in Barcelona, September 23-26, 2019.

At the exhibition (booth 601), the latest version of our translational safety intelligence portal OFF-X will be presented, including the OFF-X Score (a tool to identify the degree of association between targets/drugs and adverse effects in the corpus of more than 410,000 alerts in OFF-X), and new analytics enhancements such as the comparative drug safety heatmaps, the mounting evidence chart and the comparative table builder.

Since its launch in 2017, Bioinfogate OFF-X has been providing integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of R&D, including first-in-class and emerging targets. OFF-X allows prompt identification of toxicology and safety signals and de-risking of R&D projects. As of September 2019, the portal covers a range of almost 8,200 targets and 14,000 drugs & biologics, and is populated with more than 410,000 expertly curated safety alerts and 500,000 references of interest associated to 5,000 adverse effects. OFF-X is used across pharma and biotech organizations, in leading research centers and regulatory bodies (for more information visit www.targetsafety.info).

A series of case studies will be presented to demonstrate OFF-X’s utility for a wide variety of professionals including:

  • Biologists and Bioinformaticians, to perform new target safety assessment
  • Medicinal Chemists, to identify potential toxicophores and optimize hit compounds
  • Data Scientists, to build predictive and AI models using OFF-X’s high quality curated and structured dataset
  • Toxicologists and Non-Clinical Safety Researchers, to analyze data for regulatory endpoints of interest, assess secondary pharmacology and potential off-target liabilities
  • Clinical Researchers, to optimize clinical trial design, understand mechanistic toxicity of adverse events observed in clinical trials and to benchmark competitors’ safety profiles
  • Pharmacovigilance teams to discover unknown adverse events and support understanding of safety alerts
  • Regulatory professionals, to facilitate mandatory reporting requirements of regulatory bodies
  • Business Development Analysts, to enhance due diligence of potential in-licensing opportunities

For further information or to schedule a meeting during the conference, please contact info@bioinfogate.com.

 

About the Safety Pharmacology Society

The Safety Pharmacology Society is a nonprofit organization that promotes knowledge, development, application, and training in safety pharmacology. It aims to bridge disciplines to predict, identify, characterize, monitor, and mitigate potentially undesirable pharmacodynamic activities in nonclinical studies and guide their translation into clinical trials and beyond, to benefit all patients.

 

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying and investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007; acquired by Thomson Reuters in 2007), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

RESEARCH INSTITUTES OF SWEDEN (RISE) INITIATES SUBSCRIPTION TO BIOINFOGATE OFF-X

Barcelona, June 20, 2019

 

Bioinfogate announced today the signing of a licensing agreement with RISE to access Bioinfogate’s translational safety intelligence portal, OFF-X.

RISE selected OFF-X to support the work of researchers in drug R&D to perform target safety assessment for early projects. The agreement involves the use of OFF-X safety intelligence portal to more quickly and precisely identify potential adverse events resulting from treatment with new and existing drugs.

By delivering critical integrated preclinical toxicity and clinical adverse event intelligence coupled to advanced analytics, Bioinfogate OFF-X™ allows safety liabilities to be monitored and anticipated across all phases of drug R&D. Updated daily with expertly curated safety alerts, as of June 2019, the portal covers a range of 7,700 targets and more than 10,000 drugs & biologics, and is populated with more than 340,000 alerts associated to 5,000 adverse effects. OFF-X covers targets and drugs in all stages of drug R&D development from emerging and first-in-class targets to drugs that have reached the marketplace. OFF-X aims to promptly identify toxicology & safety signals and de-risk R&D programs.

“We are very pleased that RISE is joining the growing number of leading research institutions using OFF-X as an essential tool for their drug safety and toxicology related activities” commented Josep Prous, Jr., Executive Director, Bioinfogate.

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Bioinfogate helps companies, academic institutions, and government and regulatory agencies working in scientific research and drug R&D. Our innovative knowledge management tools and analytics software solutions support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying and investing in emerging projects that align with our core business in life sciences and data analytics.

Our passion and capabilities stem from more than 60 years’ experience creating and managing biomedical knowledge, first at Prous Science (acquired by Thomson Reuters in 2007), and then at the Prous Institute for Biomedical Research. Bioinfogate is the next generation firm within the Prous family of companies, embracing a long tradition and expertise in scientific knowledge management.

For more information please contact us at media@bioinfogate.com.

VHIO AND BIOINFOGATE PARTNER TO ENHANCE SAFETY ASSESSMENT IN CLINICAL RESEARCH

Announced today, the Vall d´Hebron Institute of Oncology – Bioinfogate collaboration will validate the utility of the OFF-X translational safety intelligence portal in the design of novel clinical trials, including first-in-human studies.

Barcelona, June 17, 2019

The Vall d´Hebron Institute of Oncology (VHIO) and Bioinfogate have launched a collaborative agreement to analyze new opportunities in optimizing safety assessment and minimizing patient risk in oncology clinical trials. This partnership will seek to establish how integrating preclinical toxicity and clinical safety intelligence facilitates a translational research approach and increases understanding of the safety profile of new treatments.

The agreement involves the use of publicly available information published in Bioinfogate’s OFF-X translational safety intelligence portal to more quickly and precisely identify potential adverse events resulting from treatment with new therapies that are either about to enter clinical trials or are under current clinical development.

A first milestone of the collaboration will be to assess the value of the new OFF-X Score system to identify the degree of association between targets/drugs and adverse effects in the corpus of more than 340,000 alerts available in OFF-X.

Throughout this collaboration, VHIO will bring its renowned expertise and know-how in pioneering early clinical drug development to evaluate and advise on newly introduced functionalities of the OFF-X platform. These efforts focus on advancing and accelerating the development of more effective and safer anti-cancer therapies, set firmly within the context of precision medicine in oncology.

“Only by factoring in important preclinical insights into clinical study design will we be better equipped to predict, ameliorate and alleviate side effects experienced by patients participating in clinical trials, now and in the future” commented Elena Garralda, Director of VHIO’s Research Unit for Molecular Therapy of Cancer (UITM) – “la Caixa”, and Principal Investigator of its Early Clinical Drug Development.

“Toxicity and safety assessment represent, along with a deeper understanding of disease processes, next generation experimental models and biomarkers, one of the cornerstones of finding and developing new anticancer therapies. We are very pleased to partner with VHIO, a leading research organization in the field, to demonstrate the usefulness of OFF-X in the clinical setting” commented Josep Prous, Jr., Executive Director, Bioinfogate.

 

About Vall D’Hebron Institute of Oncology

Established in 2006, the Vall d´Hebron Institute of Oncology (VHIO) is a leading comprehensive cancer center of excellence where scientists and research physicians adopt a purely translational research model and work together as multidisciplinary teams to accelerate and advance personalized and targeted therapies against cancer. Undertaking one of Spain’s most dynamic cancer research programs, VHIO is dedicated to delivering on the promise of precision medicine in oncology – turning cancer discovery into more effective treatments and better practice for the care of their patients. Located within the Vall d’Hebron Barcelona Hospital Campus, translational science and clinical research are tightly connected and promote the necessary interaction and teamwork to accelerate the bench-bedside-bed cycle of knowledge. VHIO’s pioneering model and programs, coupled with its belief in combining strengths through cross-border collaborations, continue to spur advances in reversing cancer resistance, halting metastatic cell spread, and more effectively treating even the most undruggable tumor types.

 

About Bioinfogate OFF-X™

Bioinfogate, a leading data science organization, is the producer of the OFF-X translational safety intelligence portal (www.targetsafety.info). By delivering critical integrated preclinical toxicity and clinical adverse event intelligence coupled to advanced analytics, Bioinfogate OFF-X™ allows safety liabilities to be monitored and anticipated across all phases of drug R&D. Updated daily with expertly curated safety alerts, as of June 2019, the portal covers a range of 7,700 targets and more than 10,000 drugs & biologics, and is populated with more than 340,000 alerts associated to 5,000 adverse effects. OFF-X covers targets and drugs in all stages of drug R&D development from emerging and first-in-class targets to drugs that have reached the marketplace. OFF-X aims to promptly identify toxicology & safety signals and de-risk R&D programs.

For more information please contact us at media@bioinfogate.com