BIOINFOGATE’S OFF-X REACHES HALF MILLION SAFETY ALERTS

OFF-X has become the largest translational safety and toxicity intelligence portal for drugs and targets of pharmacological interest.

Barcelona, January 13, 2020

Launched in 2017, OFF-X has now reached 500,000 curated safety alerts corresponding to almost 15,000 targets of pharmacological interest and almost 14,500 drugs and biologics.

Unexpected safety issues still constitute one of the major challenges in drug R&D and clinical practice. It is therefore essential to rapidly identify these issues and react accordingly to minimize risks in pharmaceutical programs.

To help in this endeavor, Bioinfogate has developed OFF-X, the translational safety intelligence portal, which provides integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of R&D, including first-in-class and emerging targets.

The database is updated daily with information deriving from biomedical literature, congresses and scientific conferences, company communications, major clinical trial registries, pharmacovigilance data and regulatory agencies, and includes data from the last 50 years.

On reaching this milestone Dr Josep Prous, Jr, Executive Director at Bioinfogate commented:

“We are very pleased that OFF-X has become an essential tool for all those involved in finding better and safer drugs. Our editorial team – comprised of specialists in multiple biomedical research disciplines – has made an outstanding contribution in producing such a large amount of curated information. We look forward to further developing the platform to help optimize pharmaceutical R&D and minimize patient risks in clinical trials and beyond”.

By enabling translational research, OFF-X allows safety liabilities to be monitored and anticipated across all phases of drug R&D and postmarketing. OFF-X is used across a wide range of departments in pharmaceutical research organizations, public health institutions and regulatory agencies.

Along with the large amount of information available in OFF-X, a series of advanced analytics allow users to fully exploit the OFF-X dataset.

 

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying / investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007), acquired by Thomson Reuters in 2007 (now Clarivate Analytics), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

BIOINFOGATE TO PRESENT AT THE CHEM-BIO INFORMATICS SOCIETY (CBI) ANNUAL MEETING (TOKYO, JAPAN, OCTOBER 22-24, 2019)

October 10, 2019

Bioinfogate has been invited to a speak at the Chem-Bio Informatics Society (CBI) Annual Meeting “”Towards Seamless Integration of Structural Biology and Information Science”~Dawn of the AI era in drug discovery~” which takes place in Tokyo, Oct. 22-24, 2019.

During the Focused Session FS13 “Computational toxicology – practical and application”, (Wed Oct. 23, 16:00-17:30), Dr Josep Prous, Jr., Executive Director at Bioinfogate will present “THE IMPORTANCE OF A SOLID KNOWLEDGE MANAGEMENT STRATEGY IN COMPUTATIONAL TOXICOLOGY”.

Given the continuous growth of safety and toxicity information, it is essential to design an adequate knowledge management plan to identify the most relevant safety hotspots to be analyzed in the context of a research project.

In his presentation, Dr Prous, Jr. will explain how the availability of a large amount of high quality, manually curated information has allowed scoring functions to be developed in order to identify safety hotspots which may be readily applicable in computational toxicology programs.

This approach has been integrated into the OFF-X translational safety intelligence portal which provides integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of drug R&D, including first-in-class and emerging targets.

For further information or to schedule a meeting during the conference, please contact info@bioinfogate.com.

 

About the Chem-Bio Informatics Society  

The Chem-BioInformatics (CBI) Society is a Japanese non-profit organization that aims to provide a platform for promoting cutting-edge interdisciplinary areas related to chemistry, biology, and informatics. The CBI Society is interested in molecular recognition and molecular modeling, in silico drug discovery, bioinformatics and their applications in medicine, information and computing approaches for drug design and ADMET studies, and emerging new technologies.

 

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry leading solutions and also identifying and investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007), acquired by Thomson Reuters in 2007 (now Clarivate Analytics), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

BIOINFOGATE EXHIBITING AT THE SAFETY PHARMACOLOGY SOCIETY ANNUAL MEETING IN BARCELONA (SEPTEMBER 23-25, 2019)

Barcelona, September 20, 2019

Bioinfogate will be showcasing some of their recent developments at the Safety Pharmacology Society Annual Meeting in Barcelona, September 23-26, 2019.

At the exhibition (booth 601), the latest version of our translational safety intelligence portal OFF-X will be presented, including the OFF-X Score (a tool to identify the degree of association between targets/drugs and adverse effects in the corpus of more than 410,000 alerts in OFF-X), and new analytics enhancements such as the comparative drug safety heatmaps, the mounting evidence chart and the comparative table builder.

Since its launch in 2017, Bioinfogate OFF-X has been providing integrated preclinical toxicity and clinical adverse event intelligence for drugs and targets in all phases of R&D, including first-in-class and emerging targets. OFF-X allows prompt identification of toxicology and safety signals and de-risking of R&D projects. As of September 2019, the portal covers a range of almost 8,200 targets and 14,000 drugs & biologics, and is populated with more than 410,000 expertly curated safety alerts and 500,000 references of interest associated to 5,000 adverse effects. OFF-X is used across pharma and biotech organizations, in leading research centers and regulatory bodies (for more information visit www.targetsafety.info).

A series of case studies will be presented to demonstrate OFF-X’s utility for a wide variety of professionals including:

  • Biologists and Bioinformaticians, to perform new target safety assessment
  • Medicinal Chemists, to identify potential toxicophores and optimize hit compounds
  • Data Scientists, to build predictive and AI models using OFF-X’s high quality curated and structured dataset
  • Toxicologists and Non-Clinical Safety Researchers, to analyze data for regulatory endpoints of interest, assess secondary pharmacology and potential off-target liabilities
  • Clinical Researchers, to optimize clinical trial design, understand mechanistic toxicity of adverse events observed in clinical trials and to benchmark competitors’ safety profiles
  • Pharmacovigilance teams to discover unknown adverse events and support understanding of safety alerts
  • Regulatory professionals, to facilitate mandatory reporting requirements of regulatory bodies
  • Business Development Analysts, to enhance due diligence of potential in-licensing opportunities

For further information or to schedule a meeting during the conference, please contact info@bioinfogate.com.

 

About the Safety Pharmacology Society

The Safety Pharmacology Society is a nonprofit organization that promotes knowledge, development, application, and training in safety pharmacology. It aims to bridge disciplines to predict, identify, characterize, monitor, and mitigate potentially undesirable pharmacodynamic activities in nonclinical studies and guide their translation into clinical trials and beyond, to benefit all patients.

 

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Our innovative data science products support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying and investing in emerging projects that align with our core business in the life sciences and data analytics.

Our passion and capabilities stem from more than 60 years of experience creating and managing biomedical knowledge, first at Prous Science (1958-2007; acquired by Thomson Reuters in 2007), and then at Prous Institute for Biomedical Research. Bioinfogate is the latest initiative within the Prous family group of companies embracing a long tradition and expertise in scientific knowledge management.

RESEARCH INSTITUTES OF SWEDEN (RISE) INITIATES SUBSCRIPTION TO BIOINFOGATE OFF-X

Barcelona, June 20, 2019

 

Bioinfogate announced today the signing of a licensing agreement with RISE to access Bioinfogate’s translational safety intelligence portal, OFF-X.

RISE selected OFF-X to support the work of researchers in drug R&D to perform target safety assessment for early projects. The agreement involves the use of OFF-X safety intelligence portal to more quickly and precisely identify potential adverse events resulting from treatment with new and existing drugs.

By delivering critical integrated preclinical toxicity and clinical adverse event intelligence coupled to advanced analytics, Bioinfogate OFF-X™ allows safety liabilities to be monitored and anticipated across all phases of drug R&D. Updated daily with expertly curated safety alerts, as of June 2019, the portal covers a range of 7,700 targets and more than 10,000 drugs & biologics, and is populated with more than 340,000 alerts associated to 5,000 adverse effects. OFF-X covers targets and drugs in all stages of drug R&D development from emerging and first-in-class targets to drugs that have reached the marketplace. OFF-X aims to promptly identify toxicology & safety signals and de-risk R&D programs.

“We are very pleased that RISE is joining the growing number of leading research institutions using OFF-X as an essential tool for their drug safety and toxicology related activities” commented Josep Prous, Jr., Executive Director, Bioinfogate.

About Bioinfogate

Bioinfogate is a forward thinking, private company working to solve unmet medical needs. Bioinfogate helps companies, academic institutions, and government and regulatory agencies working in scientific research and drug R&D. Our innovative knowledge management tools and analytics software solutions support the discovery and development of better and safer drugs. We are committed to building industry-leading solutions and identifying and investing in emerging projects that align with our core business in life sciences and data analytics.

Our passion and capabilities stem from more than 60 years’ experience creating and managing biomedical knowledge, first at Prous Science (acquired by Thomson Reuters in 2007), and then at the Prous Institute for Biomedical Research. Bioinfogate is the next generation firm within the Prous family of companies, embracing a long tradition and expertise in scientific knowledge management.

For more information please contact us at media@bioinfogate.com.